{"id":35981,"date":"2023-04-28T10:39:44","date_gmt":"2023-04-28T08:39:44","guid":{"rendered":"https:\/\/staging.futurehealthbiobank.com\/al\/?p=35981"},"modified":"2023-04-28T10:39:44","modified_gmt":"2023-04-28T08:39:44","slug":"mrekulli-e-mjekesise-infeksioni-hiv-u-kurua-tek-pacienti-saje-transplantit-te-qelizave-staminale","status":"publish","type":"post","link":"https:\/\/staging.futurehealthbiobank.com\/al\/blog\/mrekulli-e-mjekesise-infeksioni-hiv-u-kurua-tek-pacienti-saje-transplantit-te-qelizave-staminale\/","title":{"rendered":"Mrekulli e Mjek\u00ebsis\u00eb: Infeksioni HIV “U Kurua” tek Pacienti Saj\u00eb Transplantit t\u00eb Qelizave Staminale"},"content":{"rendered":"

Shkenc\u00ebtar\u00ebt dhe profesionist\u00ebt e mjeksis\u00eb kan\u00eb k\u00ebrkuar prej koh\u00ebsh nj\u00eb kur\u00eb p\u00ebr infeksionin HIV, nj\u00eb virus ky potencialisht vdekjeprur\u00ebs i cili ka prekur tashm\u00eb nj\u00eb shif\u00ebr t\u00eb vler\u00ebsuar prej 38 milion njer\u00ebz n\u00eb mbar\u00eb bot\u00ebn.<\/a><\/p>\n

Nd\u00ebrsa terapia me antiretroviral\u00eb (ART) ka b\u00ebr\u00eb hapa t\u00eb m\u00ebdhenj p\u00ebrpara n\u00eb manaxhimin e infeksionit HIV, e ardhmja p\u00ebr nj\u00eb kur\u00eb mbetet ende nj\u00eb iluzion. Megjithat\u00eb, zhvillimet e fundit n\u00eb terapin\u00eb me qeliza staminale sugjerojn\u00eb se nj\u00eb kur\u00eb p\u00ebr infeksionin HIV mund t\u00eb jet\u00eb e mundshme n\u00eb t\u00eb ardhmen e af\u00ebrt.<\/p>\n

Sipas studimi t\u00eb ri botuar n\u00eb revist\u00ebn Nature<\/a>, nj\u00eb burr\u00eb 53 vje\u00e7ar, u b\u00eb, t\u00eb pakt\u00ebn, personi i tret\u00eb me HIV i cili deklarohet i pastruar nga ky virus. Duke ndjekur me v\u00ebmendje k\u00ebt\u00eb sukses, shkenc\u00ebtar\u00ebt po e marrin seriozisht mund\u00ebsin\u00eb e p\u00ebrdorimit t\u00eb transplanteve t\u00eb qelizave staminale dhe inxhinierimin gjenetik p\u00ebr t\u00eb kuruar infeksionin HIV.<\/p>\n

Historia e burrit gjerman i njohur si pacienti i Dyseldorfit ka fuqizuar k\u00ebrkimet p\u00ebr nj\u00eb kur\u00eb t\u00eb HIV dhe ka hedhur drit\u00eb mbi rrug\u00eb t\u00eb reja p\u00ebr k\u00ebrkimet rreth HIV. K\u00ebtu ne hedhim nj\u00eb v\u00ebshtrim t\u00eb thelluar n\u00eb historin\u00eb e k\u00ebtij pacienti dhe p\u00ebr t\u00eb kuptuar n\u00ebse ajo mund t\u00eb thot\u00eb se ne kemi gjetur nj\u00eb kur\u00eb p\u00ebr infeksionin HIV.<\/p>\n

Nj\u00eb Rast Studimor i Jashtzakonsh\u00ebm: Transplanti i Qelizave Staminale Kuron Infeksionin HIV<\/strong><\/h3>\n

N\u00eb 2013, burri 53 vje\u00e7ar nga Dyseldorfi, Gjermani, ju n\u00ebnshtrua nj\u00eb transplanti qelizash staminale p\u00ebr trajtimin e limfom\u00ebs Hodgkin. <\/p>\n

Transplanti ishte i suksessh\u00ebm dhe limfoma e k\u00ebtij pacienti kaloi n\u00eb remision. Megjithat\u00eb, ajo \u00e7ka e b\u00ebri k\u00ebt\u00eb rast t\u00eb jashtzakonsh\u00ebm ishte fakti se qelizat staminale t\u00eb p\u00ebrdorura p\u00ebr transplantin ishin me burim nga nj\u00eb dhurues me nj\u00eb mutacion gjenetik t\u00eb rrall\u00eb i cili i b\u00ebnte ato imune ndaj infeksionit HIV.<\/p>\n

Testet fillestare pas transplantit t\u00eb qelizave staminale treguan se pacienti kishte ende gjurm\u00eb t\u00eb virusit, por infeksioni nuk po replikohej. Nd\u00ebsa virusi HIV q\u00ebndronte n\u00eb trup gjat\u00eb terapis\u00eb me antiretroviral\u00eb, ekipi mjeksor vendosi t\u00eb shihte se \u00e7far\u00eb do t\u00eb ndodhte n\u00ebse ai e ndalonte fare terapin\u00eb ART. <\/p>\n

N\u00eb m\u00ebnyr\u00eb t\u00eb jashtzakonshme, pacienti ishte n\u00eb gj\u00ebndje ta ndalonte krejt\u00ebsisht terapin\u00eb me antiretroviral\u00eb dhe ishte n\u00eb thelb pa prezenc\u00ebn e virusit HIV p\u00ebr mbi dy vjet – pa ndonj\u00eb rikthim n\u00eb nivelet e virusit prej niveleve shum\u00eb t\u00eb ul\u00ebta t\u00eb tij.<\/p>\n

Ky rast studimor q\u00ebndron midis mjfat t\u00eb tjer\u00ebve q\u00eb na sugjerojn\u00eb se nj\u00eb kur\u00eb p\u00ebr infeksionin HIV mund t\u00eb jet\u00eb e mundshme p\u00ebrmes p\u00ebrdorimit t\u00eb transplanteve t\u00eb qelizave staminale dhe inxhinierimit gjenetik. Timothy Ray Brown ishte pacienti i par\u00eb i cili u konsiderua i kuruar nga HIV<\/a> n\u00eb 2008. Sikurse dhe Pacientit i Dyseldorfit, edhe Brown ju n\u00ebnshtrua transplanteve t\u00eb qelizave staminale p\u00ebr kancerin, nga nj\u00eb dhurues i cili ishte imun ndaj infeksionit HIV. Mjek\u00ebt deklaruan se Brown ishte kuruar tashm\u00eb, jo shum\u00eb koh\u00eb pas transplantit t\u00eb qelizave staminale tek ai.<\/p>\n

Nj\u00eb pacient tjet\u00ebr, 40-vje\u00e7ari Adam Castillejo, kishte marr\u00eb nj\u00eb transplant<\/a> t\u00eb palc\u00ebs n\u00eb 2016 p\u00ebr trajtimin e limfom\u00ebs Hodgkin. Edhe dhurimi i palc\u00ebs p\u00ebr t\u00eb erdhi gjithashtu prej dikujt q\u00eb e kishte mutacionin dhe ai u deklarua i kuruar prej infeksionit HIV n\u00eb 2019.<\/p>\n

Dep\u00ebrtime Potenciale p\u00ebr K\u00ebrkimet Shkencore p\u00ebr Kur\u00ebn e HIV<\/strong><\/h3>\n

Rastet e pacientit t\u00eb Dyseldorfit dhe pacient\u00ebve t\u00eb tjer\u00eb jan\u00eb duke pikturuar nj\u00eb tabllo t\u00eb shk\u00eblqyer p\u00ebr t\u00eb ardhmen e k\u00ebrkimeve rreth kur\u00ebs p\u00ebr HIV.<\/p>\n

Shkenc\u00ebtar\u00ebt po eksplorojn\u00eb p\u00ebrdorimin e teknikave t\u00eb modifikimit t\u00eb gjenomit, si\u00e7 \u00ebsht\u00eb ajo CRISPR-Cas9, p\u00ebr t\u00eb krijuar mutacion gjenetik t\u00eb ngjash\u00ebm n\u00eb qelizat staminale t\u00eb vet\u00eb pacientit<\/a>. Qelizat e modifikuara do t\u00eb transplantohen pas tek vet\u00eb pacienti si nj\u00eb transplant autolog.<\/p>\n

Kjo qasje \u00ebsht\u00eb t\u00ebrheq\u00ebse pasi \u00ebsht\u00eb mjaft praktike dhe m\u00eb pak e rrezikshme se sa p\u00ebrdorimi i qelizave prej dhuruesve. Aktualisht, terapia me qeliza staminale, me shum\u00eb gjasa, nuk do t\u00eb p\u00ebrdoret tek pacient\u00ebt me HIV t\u00eb cil\u00ebt nuk kan\u00eb gjithashtu edhe leu\u00e7emi, p\u00ebr pasoj\u00eb t\u00eb komplikacioneve nga p\u00ebrdorimi i qelizave nga dhurues. Terapit\u00eb me qeliza staminale autologe me qeliza t\u00eb modifikuara mund t\u00eb shtrojn\u00eb rrug\u00ebn p\u00ebr nj\u00eb kur\u00eb t\u00eb shkall\u00ebzuar dhe kostoefektive p\u00ebr kurimin e HIV.<\/p>\n

Nd\u00ebrsa ka ende nj\u00eb rrug\u00eb t\u00eb gjat\u00eb p\u00ebr t\u00eb b\u00ebr\u00eb n\u00eb terma t\u00eb zhvillimit t\u00eb nj\u00eb kure t\u00eb shkall\u00ebzuar dhe kostoefektive p\u00ebr HIV, ky rast studimor i \u00ebsht\u00eb shtuar baz\u00ebs n\u00eb zhvillim t\u00eb fakteve q\u00eb tregojn\u00eb se transplantet e qelizave staminale jan\u00eb rruga e duhur p\u00ebrpara p\u00ebr eleminimin nj\u00eb her\u00eb e p\u00ebrgjithnj\u00eb t\u00eb virusit.<\/p>\n","protected":false},"excerpt":{"rendered":"

Shkenc\u00ebtar\u00ebt dhe profesionist\u00ebt e mjeksis\u00eb kan\u00eb k\u00ebrkuar prej koh\u00ebsh nj\u00eb kur\u00eb p\u00ebr infeksionin HIV, nj\u00eb virus ky potencialisht vdekjeprur\u00ebs i cili ka prekur tashm\u00eb nj\u00eb shif\u00ebr t\u00eb vler\u00ebsuar prej 38 milion njer\u00ebz n\u00eb mbar\u00eb bot\u00ebn. Nd\u00ebrsa terapia me antiretroviral\u00eb (ART) ka b\u00ebr\u00eb hapa t\u00eb m\u00ebdhenj p\u00ebrpara n\u00eb manaxhimin e infeksionit HIV, e ardhmja p\u00ebr nj\u00eb […]<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[216],"tags":[],"class_list":["post-35981","post","type-post","status-publish","format-standard","hentry","category-perditesime-klinike"],"acf":[],"yoast_head":"\nMrekulli e Mjek\u00ebsis\u00eb: Infeksioni HIV "U Kurua" tek Pacienti Saj\u00eb Transplantit t\u00eb Qelizave Staminale - Future Health Biobank Albania<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"sq_AL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mrekulli e Mjek\u00ebsis\u00eb: Infeksioni HIV "U Kurua" tek Pacienti Saj\u00eb Transplantit t\u00eb Qelizave Staminale - Future Health Biobank Albania\" \/>\n<meta property=\"og:description\" content=\"Shkenc\u00ebtar\u00ebt dhe profesionist\u00ebt e mjeksis\u00eb kan\u00eb k\u00ebrkuar prej koh\u00ebsh nj\u00eb kur\u00eb p\u00ebr infeksionin HIV, nj\u00eb virus ky potencialisht vdekjeprur\u00ebs i cili ka prekur tashm\u00eb nj\u00eb shif\u00ebr t\u00eb vler\u00ebsuar prej 38 milion njer\u00ebz n\u00eb mbar\u00eb bot\u00ebn. 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