{"id":32450,"date":"2024-07-05T10:21:40","date_gmt":"2024-07-05T08:21:40","guid":{"rendered":"https:\/\/staging.futurehealthbiobank.com\/rs\/?p=32450"},"modified":"2024-07-05T10:47:52","modified_gmt":"2024-07-05T08:47:52","slug":"stem-cells-assist-uks-first-rejection-free-kidney-transplant","status":"publish","type":"post","link":"https:\/\/staging.futurehealthbiobank.com\/rs\/blog\/stem-cells-assist-uks-first-rejection-free-kidney-transplant\/","title":{"rendered":"Mati\u010dne \u0107elije poma\u017eu prvoj britanskoj transplantaciji bubrega bez odbacivanja"},"content":{"rendered":"<p>Transplantacije mati\u010dnih c\u0301elija se obi\u010dno primenjuju u slo\u017eenim procedurama kako bi se pomoglo u le\u010denju odre\u0111enog stanja ili bolesti. Ali, kao jedinstvene mati\u010dne c\u0301elije tela, mati\u010dne c\u0301elije tako\u0111e imaju \u0161irok spektar primena koje se prou\u010davaju i praktikuju.<\/p>\n<p>Jedna od ovih aplikacija koje najvi\u0161e obec\u0301ava, kao \u0161to je pokazano u izuzetnom nedavno objavljenom slu\u010daju Aditi Shankar, je podr\u0161ka procesu oporavka nakon transplantacije organa.<\/p>\n<p>Osomogodi\u0161nja Aditi \u0160ankar postala je <a href=\"https:\/\/www.bbc.co.uk\/news\/health-66879093\" target=\"_blank\" rel=\"noopener\">prvo dete u Velikoj Britaniji<\/a> koje je primilo odre\u0111enu vrstu transplantacije bubrega bez potrebe za dugoro\u010dnim lekovima za spre\u010davanje odbacivanja organa.<\/p>\n<p>Nekoliko nedelja posle transplantacije, Aditi je prestala da uzima imunosupresivne lekove, koji se obi\u010dno moraju uzimati svakodnevno. Kako lekovi deluju tako \u0161to potiskuju imuni sistem, pove\u0107avaju rizik od infekcije i \u010desto izazivaju dugoro\u010dne nuspojave, uklju\u010duju\u0107i mu\u010dninu, dijabetes, umor, povra\u0107anje i osteoporozu, izme\u0111u ostalog.<\/p>\n<p>Zahvaljuju\u0107i uspehu procedure, Aditi se sada vratila u \u0161kolu sa transplantiranim bubregom i normalnim radom imunolo\u0161kog sistema.<\/p>\n<h2>Eliminacija potrebe za imunosupresijom<\/h2>\n<p>Aditi ima \u0160imkeovu imuno-ko\u0161tanu displaziju (SIOD), izuzetno retko geneti\u010dko stanje koje je oslabilo njen imunolo\u0161ki sistem i dovelo do otkazivanja bubrega.<\/p>\n<p>Specijalisti u bolnici Great Ormond Street su prvo razgovarali sa me\u0111unarodnim kolegama o pristupu transplantacije uz pomo\u0107 mati\u010dnih \u0107elija, koji je ve\u0107 kori\u0161\u0107en kod druge dece sa SIOD-om.<\/p>\n<p>Isprva, mati\u010dne \u0107elije su prikupljene iz ko\u0161tane sr\u017ei Aditine majke. Donorske \u0107elije od roditelja su uvek polovi\u010dno podudarne za njihovu decu, dok bra\u0107a i sestre imaju 50% \u0161anse za podudarnost.<\/p>\n<p>Mati\u010dne c\u0301elije ko\u0161tane sr\u017ei su zatim transplantirane u krvotok Aditi. \u0160est meseci kasnije, nakon \u0161to su mati\u010dne c\u0301elije uspe\u0161no obnovile njen imuni sistem, Aditi je dobila transplantaciju bubrega, koju je ponovo donirala njena majka (najmanje 50% \u0161anse da se potpuni humani leukocitni antigen (HLA) podudara), i njen imuni sistem je prihvatio organ.<\/p>\n<p>Prof. Stiven Marks, de\u010diji specijalista za bubrege u GOSH, ka\u017ee da se \u010dini da je Aditin tretman bio uspe\u0161an i da su je samo mesec dana nakon transplantacije mogli skinuti sa svih imunosupresivnih lekova.<\/p>\n<p>U ovom slu\u010daju, \u010dini se da su mati\u010dne \u0107elije pomogle Aditi da izgradi zdrav imunolo\u0161ki sistem i spre\u010di odbacivanje organa, \u0161to se de\u0161ava kada imunolo\u0161ki sistem prepozna transplantat kao strano telo. Odbacivanje izaziva reakciju koja na kraju uni\u0161tava transplantirani organ ili tkivo.<\/p>\n<p>Da bi pacijent primio transplantaciju i ne zahtevao do\u017eivotno uzimanje imunosupresivnih lekova predstavlja zna\u010dajan napredak. <a href=\"https:\/\/clinicaltrials.stanford.edu\/trials\/k\/NCT00319657.html\" target=\"_blank\" rel=\"noopener\">Nekoliko studija,<\/a> uklju\u010duju\u0107\u0301i klini\u010dko ispitivanje u programu Stanford Medical Center, dalje istra\u017euju ovaj potencijal mati\u010dnih c\u0301elija u zameni potrebe za imunosupresivnim lekovima nakon rutinskih transplantacija.<\/p>\n<p>Potrebne su dalje studije u ovoj oblasti pre nego \u0161to mati\u010dne c\u0301elije postanu redovni deo takvih procedura. Ali znaci obec\u0301avaju da c\u0301e u bliskoj buduc\u0301nosti mati\u010dne c\u0301elije pomoc\u0301i lekarima i hirurzima u prevazila\u017eenju jednog od najvec\u0301ih izazova u nezi transplantacije.<\/p>\n<p>Za vi\u0161e informacija posetite stranicu na\u0161e usluge \u010duvanja krvi iz pup\u010dane vrpce ili kontaktirajte na\u0161 tim na +381 11 44 09 981 ili <a href=\"mailto:office@medigen.rs\">office@medigen.rs<\/a>. Bi\u0107e nam drago da vas posavetujemo i podr\u017eimo na va\u0161em putu. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Transplantacije mati\u010dnih c\u0301elija se obi\u010dno primenjuju u slo\u017eenim procedurama kako bi se pomoglo u le\u010denju odre\u0111enog stanja ili bolesti. Ali, kao jedinstvene mati\u010dne c\u0301elije tela, mati\u010dne c\u0301elije tako\u0111e imaju \u0161irok spektar primena koje se prou\u010davaju i praktikuju. Jedna od ovih aplikacija koje najvi\u0161e obec\u0301ava, kao \u0161to je pokazano u izuzetnom nedavno objavljenom slu\u010daju Aditi Shankar, [&hellip;]<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-32450","post","type-post","status-publish","format-standard","hentry","category-uncategorised"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Mati\u010dne \u0107elije poma\u017eu prvoj britanskoj transplantaciji bubrega bez odbacivanja - Future Health Biobank Serbia<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"sr_RS\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mati\u010dne \u0107elije poma\u017eu prvoj britanskoj transplantaciji bubrega bez odbacivanja - Future Health Biobank Serbia\" \/>\n<meta property=\"og:description\" content=\"Transplantacije mati\u010dnih c\u0301elija se obi\u010dno primenjuju u slo\u017eenim procedurama kako bi se pomoglo u le\u010denju odre\u0111enog stanja ili bolesti. 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