{"id":9266,"date":"2019-02-27T10:18:16","date_gmt":"2019-02-27T09:18:16","guid":{"rendered":"https:\/\/staging.futurehealthbiobank.com\/si\/?p=9266"},"modified":"2019-02-27T10:18:16","modified_gmt":"2019-02-27T09:18:16","slug":"maticne-celice-proizvajajo-inzulin-za-diabetes-tipa-1","status":"publish","type":"post","link":"https:\/\/staging.futurehealthbiobank.com\/si\/blog\/maticne-celice-proizvajajo-inzulin-za-diabetes-tipa-1\/","title":{"rendered":"Mati\u010dne celice proizvajajo inzulin za diabetes tipa 1"},"content":{"rendered":"

Prvi\u010d v zgodovini so znanstveniki preoblikovali \u010dlove\u0161ke mati\u010dne celice v zrele c elice, ki proizvajajo inzulin. Preboj nas lahko popelje bli\u017eje k razvoju zdravila za diabetes tipa 1.<\/h3>\n

<\/p>\n

Inzulin je odgovoren za uravnavanje nivojev glukoze in sladkorja v krvi. Celice v trebu\u0161ni slinavki, ki proizvajajo inzulin, so pri bolnikih z to boleznijo uni\u010dene. Kar povzro\u010di veliko te\u017eav z imunskim sistemom in tudi resne okvare organov, kot je odpoved ledvic ali kap. Zato ni presenetljivo, da so raziskovalci posku\u0161ali razmno\u017eiti te \u017eivljenjsko pomembne celice v laboratoriju.<\/p>\n

V preteklosti znanstvenikom ni uspelo programirati mati\u010dne celice na na\u010din, da bi se te razvile v odrasle beta celice, posledi\u010dno se te celice niso ustrezno odzivale na nivo glukoze v krvi in niso ustrezno proizvajale inzulina. Znanstveniki na Univerzi v Kaliforniji, San Francisko pa so na\u0161li re\u0161itev. Pluripotentne mati\u010dne celice so gojili v posodah z metodo, ki je do sedaj \u0161e ni nih\u010de preizkusil.<\/p>\n

Klju\u010den princip v biologiji je, da oblika sledi funkciji, zato smo dobili idejo, da je lahko klju\u010dnega pomena za ustrezen razvoj beta celic oblikovanje oto\u010dkov<\/p><\/blockquote>\n

– Gopika Nair, PhD, UCSF Diabetes Center<\/cite><\/p>\n

Mati\u010dne celice trebu\u0161ne slinavke so umetno lo\u010dili in jih oblikovali v grozde – oto\u010dke, in tako se je njihov razvoj nadaljeval. Odzvale so se na nivo sladkorja v krvi in za\u010dele proizvajati inzulin v roku parih dni – kot odrasle celice, ki proizvajajo inzulin – kot se \u0161e nikoli ni zgodilo v laboratoriju.<\/p>\n

Raziskovalci v UCF pospe\u0161eno delajo na razvoju terapije za diabetes tipa 1 z uporabo teh mati\u010dnih celic, in na ta na\u010din lahko bomo lahko v bodo\u010de odpravili potrebno po presajanju trebu\u0161ne slinavke. Na voljo je samo okoli 1000 organov za 1,5 milijona ljudi v Ameriki, ki imajo doabetes tipa 1. Nair je povedal:<\/p>\n

Trenutna zdravljenja kot so inzulinske inekcije zdravijo samo simptom te bolezni. Na\u0161e delo ka\u017ee na nekaj vznemirljivih poti, ki bi omogo\u010dile najti zdravilo za bolezen.
\nKon\u010dno se lahko pomaknemo naprej na podro\u010djih, ki so bila do nedavnega popolnoma nedostopna\u2026 In mo\u017enosti so nesko\u010dne.<\/p><\/blockquote>\n

Referenca:
\nhttps:\/\/www.ucsf.edu\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Prvi\u010d v zgodovini so znanstveniki preoblikovali \u010dlove\u0161ke mati\u010dne celice v zrele c elice, ki proizvajajo inzulin. Preboj nas lahko popelje bli\u017eje k razvoju zdravila za diabetes tipa 1.<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[218],"tags":[],"class_list":["post-9266","post","type-post","status-publish","format-standard","hentry","category-klinicne-posodobitve"],"acf":[],"yoast_head":"\nMati\u010dne celice proizvajajo inzulin za diabetes tipa 1 | Future Health Biobank<\/title>\n<meta name=\"description\" content=\"Prvi\u010d v zgodovini so znanstveniki preoblikovali \u010dlove\u0161ke mati\u010dne celice v zrele c elice, ki proizvajajo inzulin. 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