{"id":10137,"date":"2019-02-25T13:47:27","date_gmt":"2019-02-25T13:47:27","guid":{"rendered":"https:\/\/staging.futurehealthbiobank.com\/ua\/?p=10137"},"modified":"2019-08-01T13:47:56","modified_gmt":"2019-08-01T12:47:56","slug":"cilmes-sunas-veidotas-lai-razotu-insulinu-1-tipa-cukura-diabeta-slimniekiem","status":"publish","type":"post","link":"https:\/\/staging.futurehealthbiobank.com\/ua\/blog\/cilmes-sunas-veidotas-lai-razotu-insulinu-1-tipa-cukura-diabeta-slimniekiem\/","title":{"rendered":"Cilmes \u0161\u016bnas veidotas, lai ra\u017eotu insul\u012bnu 1. tipa cukura diab\u0113ta slimniekiem"},"content":{"rendered":"

Pirmo reizi v\u0113stur\u0113 zin\u0101tnieki ir p\u0101rveidoju\u0161i cilv\u0113ku cilmes \u0161\u016bnas par nobriedu\u0161\u0101m insul\u012bnu ra\u017eotsp\u0113j\u012bg\u0101m \u0161\u016bn\u0101m. \u0160is sasniegums var\u0113tu pietuvin\u0101t m\u016bs pretdiab\u0113ta \u0101rstniec\u012bbas l\u012bdzek\u013cu izstr\u0101d\u0101\u0161anai.<\/h3>\n

<\/p>\n

Pirmo reizi v\u0113stur\u0113 zin\u0101tnieki ir p\u0101rveidoju\u0161i cilv\u0113ku cilmes \u0161\u016bnas par nobriedu\u0161\u0101m insul\u012bnu ra\u017eotsp\u0113j\u012bg\u0101m \u0161\u016bn\u0101m. \u0160is sasniegums var\u0113tu pietuvin\u0101t m\u016bs pretdiab\u0113ta \u0101rstniec\u012bbas l\u012bdzek\u013cu izstr\u0101d\u0101\u0161anai.<\/p>\n

Insul\u012bns atbild par glikozes un cukura l\u012bme\u0146a regul\u0101ciju asin\u012bs. Bet aizku\u0146\u0123a dziedzer\u012b eso\u0161\u0101s insul\u012bnu ra\u017eojo\u0161\u0101s \u0161\u016bnas tiek izn\u012bcin\u0101tas tiem pacientiem, kas slimo ar 1. tipa cukura diab\u0113tu, t\u0101d\u0113j\u0101di izraisot da\u017e\u0101das imunit\u0101tes komplik\u0101cijas un pat nopietnus org\u0101nu boj\u0101jumus, k\u0101, piem\u0113ram, nieru mazsp\u0113ja vai insults. Nav p\u0101rsteigums, ka diab\u0113ta p\u0113tnieki ir m\u0113\u0123in\u0101ju\u0161i replic\u0113t \u0161\u012bs dz\u012bvi maino\u0161as \u0161\u016bnas laboratorij\u0101.<\/p>\n

Iepriek\u0161 zin\u0101tnieki nav sp\u0113ju\u0161i p\u0101rveidot cilmes \u0161\u016bnas par piln\u012bb\u0101 nobriedu\u0161\u0101m beta \u0161\u016bn\u0101m, ne\u013caujot t\u0101m pareizi rea\u0123\u0113t uz glikozi asin\u012bs un insul\u012bna sekr\u0113ciju. Tom\u0113r zin\u0101tnieki no Kalifornijas San Francisko universit\u0101tes ir atradu\u0161i risin\u0101jumu. Vi\u0146i kultiv\u0113ja pluripotentu cilmes \u0161\u016bnas trauk\u0101, izmantojot iepriek\u0161 neizm\u0113\u0123in\u0101tu procesu.<\/p>\n

Biolo\u0123ijas pamatprincips ir t\u0101ds, ka formai seko funkcija, t\u0101p\u0113c m\u0113s izsecin\u0101j\u0101m, ka sali\u0146u veido\u0161an\u0101s var\u0113tu b\u016bt svar\u012bgs process beta \u0161\u016bnu pareizai nobrie\u0161anai.<\/p><\/blockquote>\n

– Gopika Nair, PhD, UCSF Diab\u0113ta centrs<\/cite><\/p>\n

M\u0101ksl\u012bgi atdalot aizku\u0146\u0123a dziedzera cilmes \u0161\u016bnas un p\u0101rveidojot t\u0101s sali\u0146u veid\u012bg\u0101s apvien\u012bb\u0101s, \u0161\u016bnu att\u012bst\u012bba strauji virz\u012bj\u0101s uz priek\u0161u. T\u0101s rea\u0123\u0113ja uz cukuru asin\u012bs un ra\u017eoja insul\u012bnu da\u017eu dienu laik\u0101 – k\u0101 nobriedu\u0161as insul\u012bnu ra\u017eojo\u0161as \u0161\u016bnas – veid\u0101, k\u0101ds nebija iepriek\u0161 piedz\u012bvots laboratorij\u0101.<\/p>\n

Tagad UCSF p\u0113tnieki str\u0101d\u0101 pie re\u0123enerat\u012bv\u0101m 1. tipa cukura diab\u0113ta terapij\u0101m, izmantojot \u0161\u012bs cilmes \u0161\u016bnas, kas cerams samazin\u0101s aizku\u0146\u0123a dziedzera transplant\u0101cijas nepiecie\u0161am\u012bbu. Ir pieejamas tikai 1000 uz 1,5 milj. 1. tipa cukura diab\u0113ta slimniekiem gad\u0101, dz\u012bvojo\u0161iem Amerik\u0101. Nair saka:<\/p>\n

Pa\u0161laik terapijas k\u0101 insul\u012bna injekcijas \u0101rst\u0113 tikai slim\u012bbas simptomus\u2026 Savuk\u0101rt m\u016bsu darbs ir v\u0113rsts uz vair\u0101k\u0101m aizraujo\u0161\u0101m iesp\u0113j\u0101m, lai beidzot atrastu pretl\u012bdzekli.
\nM\u0113s beidzot esam sp\u0113j\u012bgi virz\u012bties uz priek\u0161u taj\u0101s jom\u0101s, kas iepriek\u0161 ir biju\u0161as mums sl\u0113gtas\u2026 Iesp\u0113jas \u0161\u0137iet bezgal\u012bgas.<\/p><\/blockquote>\n

Atsauksmes: www.ucsf.edu\/<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Pirmo reizi v\u0113stur\u0113 zin\u0101tnieki ir p\u0101rveidoju\u0161i cilv\u0113ku cilmes \u0161\u016bnas par nobriedu\u0161\u0101m insul\u012bnu ra\u017eotsp\u0113j\u012bg\u0101m \u0161\u016bn\u0101m. \u0160is sasniegums var\u0113tu pietuvin\u0101t m\u016bs pretdiab\u0113ta \u0101rstniec\u012bbas l\u012bdzek\u013cu izstr\u0101d\u0101\u0161anai.<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[218],"tags":[],"class_list":["post-10137","post","type-post","status-publish","format-standard","hentry","category-clinical-update"],"acf":[],"yoast_head":"\nCilmes \u0161\u016bnas veidotas, lai ra\u017eotu insul\u012bnu 1. tipa cukura diab\u0113ta slimniekiem | Future Health Biobank<\/title>\n<meta name=\"description\" content=\"Pirmo reizi v\u0113stur\u0113 zin\u0101tnieki ir p\u0101rveidoju\u0161i cilv\u0113ku cilmes \u0161\u016bnas 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